Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.
|Number of pages||3|
|Journal||Infection and Immunity|
|Publication status||Published - Apr 1994|
- Bacterial Proteins
- Cell Line
- Tumor Necrosis Factor-alpha