Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

R Cockeran; H C Steel; T J Mitchell; C Feldman; R Anderson

doi:10.1128/IAI.69.5.3494-3496.2001

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

R Cockeran
, H C Steel
, T J Mitchell
, C Feldman
, R Anderson

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

Original language	English
Pages (from-to)	3494-6
Number of pages	3
Journal	Infection and Immunity
Volume	69
Issue number	5
DOIs	https://doi.org/10.1128/IAI.69.5.3494-3496.2001
Publication status	Published - May 2001

Keywords

Adult
Bacterial Proteins
Dinoprostone
Humans
Leukotriene B4
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Pneumococcal Infections
Streptolysins

Access to Document

10.1128/IAI.69.5.3494-3496.2001

Cite this

@article{e00950dbd42f4064983d371761cb804c,

title = "Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils",

abstract = "Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.",

keywords = "Adult, Bacterial Proteins, Dinoprostone, Humans, Leukotriene B4, N-Formylmethionine Leucyl-Phenylalanine, Neutrophils, Pneumococcal Infections, Streptolysins",

author = "R Cockeran and Steel, \{H C\} and Mitchell, \{T J\} and C Feldman and R Anderson",

year = "2001",

month = may,

doi = "10.1128/IAI.69.5.3494-3496.2001",

language = "English",

volume = "69",

pages = "3494--6",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

AU - Cockeran, R

AU - Steel, H C

AU - Mitchell, T J

AU - Feldman, C

AU - Anderson, R

PY - 2001/5

Y1 - 2001/5

N2 - Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

AB - Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

KW - Adult

KW - Bacterial Proteins

KW - Dinoprostone

KW - Humans

KW - Leukotriene B4

KW - N-Formylmethionine Leucyl-Phenylalanine

KW - Neutrophils

KW - Pneumococcal Infections

KW - Streptolysins

U2 - 10.1128/IAI.69.5.3494-3496.2001

DO - 10.1128/IAI.69.5.3494-3496.2001

M3 - Article

C2 - 11292782

SN - 0019-9567

VL - 69

SP - 3494

EP - 3496

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

Abstract

Keywords

Access to Document

Fingerprint

Cite this