Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

David Cleary; Vanessa Devine; Denise Morris; Karen Osman; Rebecca Gladstone; Stephen D Bentley; Saul Faust; Stuart Clarke

doi:10.1099/mgen.0.000209

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

David Cleary, Vanessa Devine, Denise Morris, Karen Osman, Rebecca Gladstone, Stephen D Bentley, Saul Faust, Stuart Clarke

Microbes, Infections and Microbiomes

Research output: Contribution to journal › Article › peer-review

Abstract

The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK’s National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children

Original language	English
Journal	Microbial Genomics
Volume	4
Issue number	9
DOIs	https://doi.org/10.1099/mgen.0.000209
Publication status	Published - 1 Sept 2018

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10.1099/mgen.0.000209

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abstract = "The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK{\textquoteright}s National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children ",

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AU - Cleary, David

AU - Devine, Vanessa

AU - Morris, Denise

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AU - Gladstone, Rebecca

AU - Bentley, Stephen D

AU - Faust, Saul

AU - Clarke, Stuart

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AB - The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK’s National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children

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ER -

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

Abstract

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