Plum-pudding gels as a platform for drug delivery: understanding the effects of the different components on the diffusion behavior of solutes

Anna Salvati, Olle Söderman, Iseult Lynch

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest effects on the diffusion of the PEG probes were related to the bulk structure, and no major effects were registered by the addition of different microgels into the hydrogel network. We attempt to rationalize this behavior in terms of the composite gel structure and discuss the results in terms of their meaning for controlled drug delivery strategies.

Original languageEnglish
Pages (from-to)7367-76
Number of pages10
JournalThe Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
Volume111
Issue number25
DOIs
Publication statusPublished - 28 Jun 2007

Keywords

  • Acrylamides
  • Cross-Linking Reagents
  • Diffusion
  • Drug Delivery Systems
  • Hydrogels
  • Magnetic Resonance Spectroscopy
  • Polyethylene Glycols
  • Solutions
  • Viscosity
  • Water

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