Plugging a Leak: How Phagosomes "Stretch" to Accommodate Pathogen Growth

Chinaemerem U Onyishi; Guillaume E Desanti; Robin C May

doi:10.1016/j.chom.2020.11.005

Plugging a Leak: How Phagosomes "Stretch" to Accommodate Pathogen Growth

Chinaemerem U Onyishi
, Guillaume E Desanti
, Robin C May

Biosciences

Research output: Contribution to journal › Article

Abstract

Phagocytes engulf pathogens into a membrane bound compartment called a phagosome, but what happens when engulfed pathogens start growing? In this issue of Cell Host & Microbe,Westman et al. (2020) show that lysosomes fuse with phagosomes to maintain phagosomal membrane integrity as the fungal pathogen Candida albicans expands.

Original language	English
Pages (from-to)	774-775
Number of pages	2
Journal	Cell Host & Microbe
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2020.11.005
Publication status	Published - 9 Dec 2020

Bibliographical note

Keywords

Candida albicans
Humans
Lysosomes
Mycoses
Phagocytes
Phagosomes

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10.1016/j.chom.2020.11.005

Cite this

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abstract = "Phagocytes engulf pathogens into a membrane bound compartment called a phagosome, but what happens when engulfed pathogens start growing? In this issue of Cell Host \& Microbe,Westman et al. (2020) show that lysosomes fuse with phagosomes to maintain phagosomal membrane integrity as the fungal pathogen Candida albicans expands.",

keywords = "Candida albicans, Humans, Lysosomes, Mycoses, Phagocytes, Phagosomes",

author = "Onyishi, \{Chinaemerem U\} and Desanti, \{Guillaume E\} and May, \{Robin C\}",

year = "2020",

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AU - Desanti, Guillaume E

AU - May, Robin C

PY - 2020/12/9

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AB - Phagocytes engulf pathogens into a membrane bound compartment called a phagosome, but what happens when engulfed pathogens start growing? In this issue of Cell Host & Microbe,Westman et al. (2020) show that lysosomes fuse with phagosomes to maintain phagosomal membrane integrity as the fungal pathogen Candida albicans expands.

KW - Candida albicans

KW - Humans

KW - Lysosomes

KW - Mycoses

KW - Phagocytes

KW - Phagosomes

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DO - 10.1016/j.chom.2020.11.005

M3 - Article

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SN - 1931-3128

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JF - Cell Host & Microbe

IS - 6

ER -

Plugging a Leak: How Phagosomes "Stretch" to Accommodate Pathogen Growth

Abstract

Bibliographical note

Keywords

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