Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time

Steve Garner, Abigail Furnell, Brennan Kahan, Chris Jones, Anthony Attwood, Paul Harrison, Anne Kelly, Alison Goodall, Rebecca Cardigan, Willem Ouwehand

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
91 Downloads (Pure)

Abstract

Background and objectives: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We aimed to measure platelet function in platelet donors over time in individuals selected from a cohort of 956 donors whose platelet function had been previously characterised.

Materials and Methods: Platelet function was assessed by flow cytometry, measuring fibrinogen binding and P-selectin expression after stimulation with either cross-linked collagen related peptide or adenosine 5’-diphosphate. Eighty nine donors from the Cambridge Platelet Function Cohort whose platelet responses were initially within the lower or upper decile of reactivity were re-tested between four months and five and a half years later.

Results: There was moderate to high correlation between the initial and repeat platelet function results for all assays (p ≤ 0.007, r2 0.2961 to 0.7625); furthermore, the range of results observed in the initial low and high responder groups remained significantly different at the time of the second test (p ≤ 0.0005).

Conclusion: Platelet function remains consistent over time. This implies that this potential influence on quality of donated platelet concentrates will remain essentially constant for a given donor.

Original languageEnglish
Pages (from-to)18-24
JournalVox Sanguinis
Volume112
Issue number1
Early online date21 Dec 2016
DOIs
Publication statusPublished - Jan 2017

Keywords

  • platelet function
  • donors
  • platelet components

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