Platelet P-selectin and platelet mass, volume and component in sickle cell disease: relationship to genotype

JS Mohan, Gregory Lip, D Bareford, Andrew Blann

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Excess platelet activation (e.g. increased soluble P selectin [sPsel] and beta thromboglobulin [beta-TG]) is well established in sickle cell disease (SCD) and may contribute to the prothrombotic/hypercoagulable state and vascular occlusion characteristic of the disease. We hypothesised altered whole platelet P-selectin (pPsel), and morphological platelet indices mass, volume and component in SCD and two of its major genotypes. METHODS: We recruited 35 SCD patients [mean age 31 years, 54% men]. Of these, 16 had homozygous sickle cell (HbSS) disease and 19 had sickle-haemoglobin-C (HbSC) disease. Patients were compared with 29 subjects with normal haemoglobin (HbAA) matched for age and ethnicity. Platelet mass, volume and component were measured by flow cytometry, pPsel in platelet lysate, sP-sel and beta-TG by ELISA. RESULTS: SCD patients had lower pP-sel and mean platelet volume (MPV) but elevated platelet component (MPC), and, as expected, elevated platelet count, and sP-sel (all p
Original languageEnglish
Pages (from-to)623-9
Number of pages7
JournalThrombosis Research
Volume117
Issue number6
DOIs
Publication statusPublished - 1 Jan 2006

Keywords

  • soluble P-selectin
  • platelet P-selectin
  • sickle cell disease

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