Platelet activation in pregnancy-induced hypertension

I Karalis, SK Nadar, E Al Yemeni, Andrew Blann, Gregory Lip

Research output: Contribution to journalArticle

26 Citations (Scopus)


BACKGROUND: Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, respectively) have not been studied. METHODS: We conducted a cross-sectional study of 35 consecutive women with PIH (age 31+/-6 years), 31 consecutive women with normotensive pregnancies (age 29+/-5 years) and 30 normotensive non pregnant women (age 30+/-5 years). Platelet adhesion was studied in vitro by binding to fibrinogen-coated microwells, platelet morphology [mass and volume by flow cytometry], whole-platelet P-selectin (pPsel) by ELISA of the lysate of 2 x 10(8) cells, and the plasma markers soluble P-selectin (sP-sel) and beta-TG, by ELISA. RESULTS: The women with PIH had significantly raised sPsel, pPsel and (as expected) beta-TG (all p
Original languageEnglish
Pages (from-to)377-83
Number of pages7
JournalThrombosis Research
Issue number5
Publication statusPublished - 1 Jan 2005


  • platelet activation
  • pregnancy-induced hypertension
  • P-selectin
  • platelet adhesion
  • preeclampsia


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