Platelet activation in pregnancy-induced hypertension

I Karalis; SK Nadar; E Al Yemeni; Andrew Blann; Gregory Lip

doi:10.1016/j.thromres.2005.01.009

Platelet activation in pregnancy-induced hypertension

I Karalis, SK Nadar, E Al Yemeni, Andrew Blann, Gregory Lip

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Abstract

BACKGROUND: Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, respectively) have not been studied. METHODS: We conducted a cross-sectional study of 35 consecutive women with PIH (age 31+/-6 years), 31 consecutive women with normotensive pregnancies (age 29+/-5 years) and 30 normotensive non pregnant women (age 30+/-5 years). Platelet adhesion was studied in vitro by binding to fibrinogen-coated microwells, platelet morphology [mass and volume by flow cytometry], whole-platelet P-selectin (pPsel) by ELISA of the lysate of 2 x 10(8) cells, and the plasma markers soluble P-selectin (sP-sel) and beta-TG, by ELISA. RESULTS: The women with PIH had significantly raised sPsel, pPsel and (as expected) beta-TG (all p

Original language	English
Pages (from-to)	377-83
Number of pages	7
Journal	Thrombosis Research
Volume	116
Issue number	5
DOIs	https://doi.org/10.1016/j.thromres.2005.01.009
Publication status	Published - 1 Jan 2005

Keywords

platelet activation
pregnancy-induced hypertension
P-selectin
platelet adhesion
preeclampsia

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10.1016/j.thromres.2005.01.009

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@article{545413c7559742aeac6f895055a803e7,

title = "Platelet activation in pregnancy-induced hypertension",

abstract = "BACKGROUND: Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, respectively) have not been studied. METHODS: We conducted a cross-sectional study of 35 consecutive women with PIH (age 31+/-6 years), 31 consecutive women with normotensive pregnancies (age 29+/-5 years) and 30 normotensive non pregnant women (age 30+/-5 years). Platelet adhesion was studied in vitro by binding to fibrinogen-coated microwells, platelet morphology [mass and volume by flow cytometry], whole-platelet P-selectin (pPsel) by ELISA of the lysate of 2 x 10(8) cells, and the plasma markers soluble P-selectin (sP-sel) and beta-TG, by ELISA. RESULTS: The women with PIH had significantly raised sPsel, pPsel and (as expected) beta-TG (all p",

keywords = "platelet activation, pregnancy-induced hypertension, P-selectin, platelet adhesion, preeclampsia",

author = "I Karalis and SK Nadar and {Al Yemeni}, E and Andrew Blann and Gregory Lip",

year = "2005",

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day = "1",

doi = "10.1016/j.thromres.2005.01.009",

language = "English",

volume = "116",

pages = "377--83",

journal = "Thrombosis Research",

publisher = "Elsevier",

number = "5",

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TY - JOUR

T1 - Platelet activation in pregnancy-induced hypertension

AU - Karalis, I

AU - Nadar, SK

AU - Al Yemeni, E

AU - Blann, Andrew

AU - Lip, Gregory

PY - 2005/1/1

Y1 - 2005/1/1

N2 - BACKGROUND: Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, respectively) have not been studied. METHODS: We conducted a cross-sectional study of 35 consecutive women with PIH (age 31+/-6 years), 31 consecutive women with normotensive pregnancies (age 29+/-5 years) and 30 normotensive non pregnant women (age 30+/-5 years). Platelet adhesion was studied in vitro by binding to fibrinogen-coated microwells, platelet morphology [mass and volume by flow cytometry], whole-platelet P-selectin (pPsel) by ELISA of the lysate of 2 x 10(8) cells, and the plasma markers soluble P-selectin (sP-sel) and beta-TG, by ELISA. RESULTS: The women with PIH had significantly raised sPsel, pPsel and (as expected) beta-TG (all p

AB - BACKGROUND: Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, respectively) have not been studied. METHODS: We conducted a cross-sectional study of 35 consecutive women with PIH (age 31+/-6 years), 31 consecutive women with normotensive pregnancies (age 29+/-5 years) and 30 normotensive non pregnant women (age 30+/-5 years). Platelet adhesion was studied in vitro by binding to fibrinogen-coated microwells, platelet morphology [mass and volume by flow cytometry], whole-platelet P-selectin (pPsel) by ELISA of the lysate of 2 x 10(8) cells, and the plasma markers soluble P-selectin (sP-sel) and beta-TG, by ELISA. RESULTS: The women with PIH had significantly raised sPsel, pPsel and (as expected) beta-TG (all p

KW - platelet activation

KW - pregnancy-induced hypertension

KW - P-selectin

KW - platelet adhesion

KW - preeclampsia

U2 - 10.1016/j.thromres.2005.01.009

DO - 10.1016/j.thromres.2005.01.009

M3 - Article

C2 - 16122550

VL - 116

SP - 377

EP - 383

JO - Thrombosis Research

JF - Thrombosis Research

IS - 5

ER -

Platelet activation in pregnancy-induced hypertension

Abstract

Keywords

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