Platelet activation in acute, decompensated congestive heart failure

Irene Chung; Anirban Choudhury; Gregory Lip

doi:10.1016/j.thromres.2007.01.003

Platelet activation in acute, decompensated congestive heart failure

Irene Chung, Anirban Choudhury, Gregory Lip

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Abstract

BACKGROUND: Congestive heart failure (CHF) is associated with increased risk of venous thromboembolism, stroke and sudden death. This may be related to abnormalities of thrombogenesis and platelet activation. A comprehensive assessment of platelet (dys)function in acute decompensated heart failure (AHF) is lacking, and we hypothesised that such patients would show greater abnormalities in platelet indices, compared to stable CHF and healthy controls. METHODS: We measured soluble P-selectin (sP-sel, by ELISA); platelet surface P-selectin (CD62P%G) and CD63%G expression by flow cytometry; and platelet structural indices [mean platelet volume (MPV), mean platelet mass (MPM) and mean platelet component (MPC)] in 22 patients with AHF (pre- and posttreatment), who were compared to 68 patients with stable congestive heart failure (CHF, all with left ventricular ejection fraction (LVEF)

Original language	English
Pages (from-to)	709-13
Number of pages	5
Journal	Thrombosis Research
Volume	120
Issue number	5
DOIs	https://doi.org/10.1016/j.thromres.2007.01.003
Publication status	Published - 1 Jan 2007

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10.1016/j.thromres.2007.01.003

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title = "Platelet activation in acute, decompensated congestive heart failure",

abstract = "BACKGROUND: Congestive heart failure (CHF) is associated with increased risk of venous thromboembolism, stroke and sudden death. This may be related to abnormalities of thrombogenesis and platelet activation. A comprehensive assessment of platelet (dys)function in acute decompensated heart failure (AHF) is lacking, and we hypothesised that such patients would show greater abnormalities in platelet indices, compared to stable CHF and healthy controls. METHODS: We measured soluble P-selectin (sP-sel, by ELISA); platelet surface P-selectin (CD62P%G) and CD63%G expression by flow cytometry; and platelet structural indices [mean platelet volume (MPV), mean platelet mass (MPM) and mean platelet component (MPC)] in 22 patients with AHF (pre- and posttreatment), who were compared to 68 patients with stable congestive heart failure (CHF, all with left ventricular ejection fraction (LVEF) ",

author = "Irene Chung and Anirban Choudhury and Gregory Lip",

year = "2007",

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doi = "10.1016/j.thromres.2007.01.003",

language = "English",

volume = "120",

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journal = "Thrombosis Research",

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TY - JOUR

T1 - Platelet activation in acute, decompensated congestive heart failure

AU - Chung, Irene

AU - Choudhury, Anirban

AU - Lip, Gregory

PY - 2007/1/1

Y1 - 2007/1/1

N2 - BACKGROUND: Congestive heart failure (CHF) is associated with increased risk of venous thromboembolism, stroke and sudden death. This may be related to abnormalities of thrombogenesis and platelet activation. A comprehensive assessment of platelet (dys)function in acute decompensated heart failure (AHF) is lacking, and we hypothesised that such patients would show greater abnormalities in platelet indices, compared to stable CHF and healthy controls. METHODS: We measured soluble P-selectin (sP-sel, by ELISA); platelet surface P-selectin (CD62P%G) and CD63%G expression by flow cytometry; and platelet structural indices [mean platelet volume (MPV), mean platelet mass (MPM) and mean platelet component (MPC)] in 22 patients with AHF (pre- and posttreatment), who were compared to 68 patients with stable congestive heart failure (CHF, all with left ventricular ejection fraction (LVEF)

AB - BACKGROUND: Congestive heart failure (CHF) is associated with increased risk of venous thromboembolism, stroke and sudden death. This may be related to abnormalities of thrombogenesis and platelet activation. A comprehensive assessment of platelet (dys)function in acute decompensated heart failure (AHF) is lacking, and we hypothesised that such patients would show greater abnormalities in platelet indices, compared to stable CHF and healthy controls. METHODS: We measured soluble P-selectin (sP-sel, by ELISA); platelet surface P-selectin (CD62P%G) and CD63%G expression by flow cytometry; and platelet structural indices [mean platelet volume (MPV), mean platelet mass (MPM) and mean platelet component (MPC)] in 22 patients with AHF (pre- and posttreatment), who were compared to 68 patients with stable congestive heart failure (CHF, all with left ventricular ejection fraction (LVEF)

U2 - 10.1016/j.thromres.2007.01.003

DO - 10.1016/j.thromres.2007.01.003

M3 - Article

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VL - 120

SP - 709

EP - 713

JO - Thrombosis Research

JF - Thrombosis Research

IS - 5

ER -

Platelet activation in acute, decompensated congestive heart failure

Abstract

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