Abstract
Background-Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothelial damage/dysfunction and platelet activation among patients with AF.
Methods and Results-We measured plasma levels of von Willebrand factor (vWF, a marker of endothelial damage/dysfunction) and soluble P-selectin (sP-sel, a marker of platelet activation) by ELISA in 1321 participants in the Stroke Prevention in Atrial Fibrillation (SPAF) III study and related these indices to the presence of stroke risk factors and cardiovascular disease. Age (P
| Original language | English |
|---|---|
| Pages (from-to) | 1962-1967 |
| Number of pages | 6 |
| Journal | Circulation |
| Volume | 106 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 8 Oct 2002 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- stroke
- von Willebrand factor
- soluble P-selectin
- risk factors
- fibrillation, atrial
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