TY - JOUR
T1 - Plasma amino acid levels in children with autism and their families
AU - Aldred, Sarah
AU - Moore, KM
AU - Fitzgerald, M
AU - Waring, Rosemary
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their siblings, and parents. The results were compared with values from age-matched controls. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenylalanine, asparagine, tyrosine, alanine, and lysine (p <.05) than controls, with reduced plasma glutamine. Other amino acids were at normal levels. These results show that children with autistic spectrum disorders come from a family background of dysregulated amino acid metabolism and provide further evidence for an underlying biochemical basis for the condition.
AB - Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their siblings, and parents. The results were compared with values from age-matched controls. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenylalanine, asparagine, tyrosine, alanine, and lysine (p <.05) than controls, with reduced plasma glutamine. Other amino acids were at normal levels. These results show that children with autistic spectrum disorders come from a family background of dysregulated amino acid metabolism and provide further evidence for an underlying biochemical basis for the condition.
KW - plasma
KW - autism
KW - amino acids
KW - glutamate/glutamine ratio
KW - Asperger syndrome
UR - http://www.scopus.com/inward/record.url?scp=0037296984&partnerID=8YFLogxK
U2 - 10.1023/A:1022238706604
DO - 10.1023/A:1022238706604
M3 - Article
C2 - 12708584
SN - 1573-3432
VL - 33
SP - 93
EP - 97
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
ER -