Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies

Shiao-yng Chan; Stivelia Kachilele; Emma Hobbs; JN Bulmer; Kristien Boelaert; Christopher McCabe; Philip Driver; J Bradwell; M Kester; TJ Visser; Jayne Franklyn; Mark Kilby

doi:10.1210/jc.2003-030228

Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies

Shiao-yng Chan, Stivelia Kachilele, Emma Hobbs, JN Bulmer, Kristien Boelaert, Christopher McCabe, Philip Driver, J Bradwell, M Kester, TJ Visser, Jayne Franklyn, Mark Kilby

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Abstract

We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (

Original language	English
Pages (from-to)	4488-4495
Number of pages	8
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	88
Issue number	9
DOIs	https://doi.org/10.1210/jc.2003-030228
Publication status	Published - 1 Sept 2003

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title = "Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies",

abstract = "We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (",

author = "Shiao-yng Chan and Stivelia Kachilele and Emma Hobbs and JN Bulmer and Kristien Boelaert and Christopher McCabe and Philip Driver and J Bradwell and M Kester and TJ Visser and Jayne Franklyn and Mark Kilby",

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AU - Chan, Shiao-yng

AU - Kachilele, Stivelia

AU - Hobbs, Emma

AU - Bulmer, JN

AU - Boelaert, Kristien

AU - McCabe, Christopher

AU - Driver, Philip

AU - Bradwell, J

AU - Kester, M

AU - Visser, TJ

AU - Franklyn, Jayne

AU - Kilby, Mark

PY - 2003/9/1

Y1 - 2003/9/1

N2 - We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (

AB - We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

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ER -

Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies

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