PK-M2 Makes Cells Sweeter on HIF1

Daniel Tennant

doi:10.1016/j.cell.2011.05.009

PK-M2 Makes Cells Sweeter on HIF1

Daniel Tennant

Cancer and Genomic Sciences

Research output: Contribution to journal › Editorial › peer-review

17 Citations (Scopus)

Abstract

The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer.

Original language	English
Pages (from-to)	647-649
Number of pages	3
Journal	Cell
Volume	145
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2011.05.009
Publication status	Published - 1 May 2011

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10.1016/j.cell.2011.05.009

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title = "PK-M2 Makes Cells Sweeter on HIF1",

abstract = "The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer.",

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AB - The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer.

U2 - 10.1016/j.cell.2011.05.009

DO - 10.1016/j.cell.2011.05.009

M3 - Editorial

C2 - 21620132

VL - 145

SP - 647

EP - 649

JO - Cell

JF - Cell

IS - 5

ER -

PK-M2 Makes Cells Sweeter on HIF1

Abstract

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