PIP3, PIP2, and cell movement--similar messages, different meanings?

Robert Insall, OD Weiner

Research output: Contribution to journalArticle

148 Citations (Scopus)


The inositol lipids PI(4,5)P(2) and PI(3,4,5)P(3) are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P(3) seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P(2) appears to be present at too high a concentration and homogeneous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P(2) acts permissively, restricting new actin polymerization to the region of the plasma membrane.
Original languageEnglish
Pages (from-to)743-7
Number of pages5
JournalDevelopmental Cell
Issue number6
Publication statusPublished - 1 Dec 2001


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