Physiological and proteomic approaches to understanding human sperm function: Prefertilization events

Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S M Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover, Christopher L R Barratt

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment because of our limited understanding of the cellular, biochemical, and molecular functioning of the spermatozoon. The underlying premise of our research program is to establish a rudimentary understanding of the processes necessary for successful fertilization. We detail advances in our understanding of calcium signaling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.

Original languageEnglish
Title of host publicationThe Genetics of Male Infertility
PublisherHumana Press
Number of pages21
ISBN (Electronic)9781597451765
ISBN (Print)9781588298638
Publication statusPublished - 1 Jan 2007


  • Calcium signaling
  • Capacitation
  • Proteomics
  • Zona pellucida

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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