Physiological and proteomic approaches to understanding human sperm function: Prefertilization events

Sarah J. Conner; Linda Lefièvre; Jackson Kirkman-Brown; Gisela S M Machado-Oliveira; Frank Michelangeli; Stephen J. Publicover; Christopher L R Barratt

doi:10.1007/978-1-59745-176-5_5

Physiological and proteomic approaches to understanding human sperm function: Prefertilization events

Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S M Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover, Christopher L R Barratt

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment because of our limited understanding of the cellular, biochemical, and molecular functioning of the spermatozoon. The underlying premise of our research program is to establish a rudimentary understanding of the processes necessary for successful fertilization. We detail advances in our understanding of calcium signaling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.

Original language	English
Title of host publication	The Genetics of Male Infertility
Publisher	Humana Press
Pages	77-97
Number of pages	21
ISBN (Electronic)	9781597451765
ISBN (Print)	9781588298638
DOIs	https://doi.org/10.1007/978-1-59745-176-5_5
Publication status	Published - 1 Jan 2007

Keywords

Calcium signaling
Capacitation
Proteomics
Zona pellucida

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology

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10.1007/978-1-59745-176-5_5

Cite this

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abstract = "Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment because of our limited understanding of the cellular, biochemical, and molecular functioning of the spermatozoon. The underlying premise of our research program is to establish a rudimentary understanding of the processes necessary for successful fertilization. We detail advances in our understanding of calcium signaling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.",

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AU - Conner, Sarah J.

AU - Lefièvre, Linda

AU - Kirkman-Brown, Jackson

AU - Machado-Oliveira, Gisela S M

AU - Michelangeli, Frank

AU - Publicover, Stephen J.

AU - Barratt, Christopher L R

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AB - Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment because of our limited understanding of the cellular, biochemical, and molecular functioning of the spermatozoon. The underlying premise of our research program is to establish a rudimentary understanding of the processes necessary for successful fertilization. We detail advances in our understanding of calcium signaling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.

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KW - Capacitation

KW - Proteomics

KW - Zona pellucida

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BT - The Genetics of Male Infertility

PB - Humana Press

ER -

Physiological and proteomic approaches to understanding human sperm function: Prefertilization events

Abstract

Keywords

ASJC Scopus subject areas

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