Photo- and electrochemical dual-responsive iridium probe for saccharide detection

Andrew Carrod, Francesco Graglia, Louise Male, Cecile Le Duff, Peter Simpson, Mohamed Elsherif, Zubair Ahmed, Haider Butt, Guang-Xi Xu, Kenneth Kam-Wing Lo, Paolo Bertoncello, Zoe Pikramenou

Research output: Contribution to journalArticlepeer-review

8 Downloads (Pure)


Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to monosaccharide binding in aqueous solution. The complex displays orange luminescence at 618 nm, which is reduced by 70 and 40 % upon binding of fructose and glucose, respectively. The electro-chemiluminescent signal of the complex also shows a direct response to monosaccharide binding. The IrIII complex shows the same response upon incorporation into hydrogel matrices as in solution, thus demonstrating the potential of its integration into a device, as a nontoxic, simple-to-use tool to observe sugar binding over physiologically relevant pH ranges and saccharide concentrations. Moreover, the complex's luminescence is responsive to monosaccharide presence in cancer cells.
Original languageEnglish
Article numbere202103541
Number of pages5
JournalChemistry: A European Journal
Early online date22 Nov 2021
Publication statusE-pub ahead of print - 22 Nov 2021

Bibliographical note

Funding Information:
The authors wish to thank EPSRC and the University of Birmingham for support of the studentship (A.J.C.).

Publisher Copyright:
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH


  • electro-chemiluminescence
  • iridium
  • luminescence
  • probes
  • saccharides
  • sensors


Dive into the research topics of 'Photo- and electrochemical dual-responsive iridium probe for saccharide detection'. Together they form a unique fingerprint.

Cite this