Pharmacology and physiological mechanisms of opioid overdose and reversal

Basak Tas, Edward Day

Research output: Chapter in Book/Report/Conference proceedingChapter


The first part of this chapter describes the pharmacological basis of opioids, with a particular focus on the potential dangers of heroin and its effects on the respiratory system. The second part introduces and describes the drug naloxone, and summarises its pharmacology, how it is metabolised and other factors that influence its function. It shows the accuracy and specificity of naloxone’s action as an opioid antagonist, how we understand its functions and why, 50 years after its original manufacture, naloxone remains the opioid antagonist of choice for reversal
of overdose
Original languageEnglish
Title of host publicationPreventing opioid overdose deaths with take-home naloxone
Publication statusPublished - 2016


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