Pharmacology and physiological mechanisms of opioid overdose and reversal

Basak Tas; Edward Day

doi:10.2810/357062

Pharmacology and physiological mechanisms of opioid overdose and reversal

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The first part of this chapter describes the pharmacological basis of opioids, with a particular focus on the potential dangers of heroin and its effects on the respiratory system. The second part introduces and describes the drug naloxone, and summarises its pharmacology, how it is metabolised and other factors that influence its function. It shows the accuracy and specificity of naloxone’s action as an opioid antagonist, how we understand its functions and why, 50 years after its original manufacture, naloxone remains the opioid antagonist of choice for reversal
of overdose

Original language	English
Title of host publication	Preventing opioid overdose deaths with take-home naloxone
DOIs	https://doi.org/10.2810/357062
Publication status	Published - 2016

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10.2810/357062

2 Article

Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?
Strang, J., McDonald, R., Tas, B. & Day, E., 1 Apr 2016, In: Addiction. 111, 4, p. 574-582 9 p.
Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus)
Stakeholder perceptions and operational barriers in the training and distribution of take-home naloxone within prisons in England
Sondhi, A., Ryan, G. & Day, E., 3 Feb 2016, In: Harm Reduction Journal. 13, 5.
Research output: Contribution to journal › Article › peer-review

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17 Citations (Scopus)

136 Downloads (Pure)

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abstract = "The first part of this chapter describes the pharmacological basis of opioids, with a particular focus on the potential dangers of heroin and its effects on the respiratory system. The second part introduces and describes the drug naloxone, and summarises its pharmacology, how it is metabolised and other factors that influence its function. It shows the accuracy and specificity of naloxone{\textquoteright}s action as an opioid antagonist, how we understand its functions and why, 50 years after its original manufacture, naloxone remains the opioid antagonist of choice for reversalof overdose",

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AB - The first part of this chapter describes the pharmacological basis of opioids, with a particular focus on the potential dangers of heroin and its effects on the respiratory system. The second part introduces and describes the drug naloxone, and summarises its pharmacology, how it is metabolised and other factors that influence its function. It shows the accuracy and specificity of naloxone’s action as an opioid antagonist, how we understand its functions and why, 50 years after its original manufacture, naloxone remains the opioid antagonist of choice for reversalof overdose

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Pharmacology and physiological mechanisms of opioid overdose and reversal

Abstract

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Research output

Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?

Stakeholder perceptions and operational barriers in the training and distribution of take-home naloxone within prisons in England

Cite this