Persistence of self-injury, aggression and property destruction in children and adults with tuberous sclerosis complex

L Wilde, K Wade, K Eden, J Moss, P J de Vries, C Oliver

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
194 Downloads (Pure)


BACKGROUND: Individuals with tuberous sclerosis complex (TSC) are at increased risk of developing self-injurious behaviour. The persistence of this deleterious behaviour over years is reported in aetiologically heterogeneous samples to be between 60% and 80% but is unknown for TSC.

METHOD: In this study, we determined the 3-year persistence of self-injury in a sample (n = 52) of children (with and without ID) and adults (with ID) with TSC and examined characteristics associated with persistence.

RESULTS: Findings for self-injury were contrasted to those for aggression and property destruction to examine the specificity of results to this behaviour. Self-injury was persistent in 84.6% of those with TSC who showed this behaviour, in contrast to 66.7% both for aggression and destruction. Persistent self-injury was associated with poor self-help skills, greater overactivity/impulsivity and more behavioural indicators of pain. These latter two characteristics were also associated with persistent aggression. No characteristics were associated with persistence of property destruction.

CONCLUSION: These findings suggest that self-injurious behaviours in individuals with TSC, together with aggressive and destructive behaviours, are highly persistent and would benefit from targeted intervention. Poor adaptive skills, overactivity/impulsivity and painful health conditions may differentiate those at most risk for persistent self-injury or aggression.

Original languageEnglish
JournalJournal of Intellectual Disability Research
Early online date8 Feb 2018
Publication statusE-pub ahead of print - 8 Feb 2018


Dive into the research topics of 'Persistence of self-injury, aggression and property destruction in children and adults with tuberous sclerosis complex'. Together they form a unique fingerprint.

Cite this