Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees

Devan Raindi, Jacqueline Rees, Josefine Hirschfeld, Helen Wright, Phillipa Dobbs, Sophie Moittie, Kate White, Wilhelm Stahl, Mike Martin, Sharon Redrobe, Francis Hughes, Matyas Liptovszky, Kerstin Baiker, Melissa Grant

Research output: Contribution to journalArticlepeer-review

Abstract

Objective
To investigate the association of dental and cardiac disease in a cohort of captive chimpanzees

Design
12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.

Results
Although the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.

Conclusions
Whilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.
Original languageEnglish
Article number105342
JournalArchives of Oral Biology
Volume134
Early online date16 Dec 2021
DOIs
Publication statusE-pub ahead of print - 16 Dec 2021

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