Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study

Hilde Marie Engjom; Rema Ramakrishnan; Nicola Vousden; Kathryn Bunch; Edward Morris; Nigel Simpson; Chris Gale; Pat O’Brien; Maria Quigley; Peter Brocklehurst; Jennifer J. Kurinczuk; Marian Knight

doi:10.1038/s41467-024-47181-z

Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study

Hilde Marie Engjom, Rema Ramakrishnan, Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Chris Gale, Pat O’Brien, Maria Quigley, Peter Brocklehurst, Jennifer J. Kurinczuk, Marian Knight^*

^*Corresponding author for this work

Birmingham Clinical Trials Unit

Research output: Contribution to journal › Article › peer-review

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Abstract

There are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.

Original language	English
Article number	3234
Number of pages	9
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-47181-z
Publication status	Published - 15 Apr 2024

Bibliographical note

Acknowledgments:
The authors would like to acknowledge the assistance of UKOSS reporting clinicians, the NIHR Reproductive Health & Childbirth Network Research Midwife Champions, and the UKOSS Steering Committee without whose support this research would not have been possible. This work has been supported by; a Institute for Health Research HS&DR Programme grant (project number 11/46/12) to M.K., M.Q., J.J.K., P.B., P.O.; a NIHR Senior Investigator grant (grant number NIHR201333) to M.K.; the Norwegian Research Council (grant no 320181) to H.M.E. The funders did not participate in the study’s design or research. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.

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Cite this

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abstract = "There are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years{\textquoteright} active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.",

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Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study

Abstract

Bibliographical note

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