Peliosis of the spleen with massive recurrent haemorrhagic ascites, despite splenectomy, associated with elevated levels of vascular endothelial growth factor

F Joseph, N Younis, Geoffrey Haydon, David Adams, S Wynne, MB Gillet, YM Maurice, ME Lipton, D Berstock, IR Jones

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14 Citations (Scopus)

Abstract

We present the case of a 33-year-old man with isolated splenic peliosis, a rare pathological condition characterized by blood filled cystic lesions. The patient presented with recurrent massive haemorrhagic ascites, which did not resolve, despite a splenectomy. He was found to have massively elevated levels of vascular endothelial growth factor (VEGF). The clinical course of the disease was prolonged. Repeated blood transfusions for recurrent anaemia were required, in addition to repeated aspiration of reaccumulating haemorrhagic ascites and pleural effusion. The clinical course was not in keeping with previously reported cases. We have described an atypical clinical presentation in a patient with isolated splenic peliosis associated with elevated VEGF concentrations. No previously known associations for the condition were found despite thorough investigations. Management of the patient has been symptomatic and palliative. We have reviewed the various reported associations of peliosis and discussed the possible role of VEGF in this patient's condition.
Original languageEnglish
Pages (from-to)1401-1406
Number of pages6
JournalEuropean Journal of Gastroenterology & Hepatology
Volume16
DOIs
Publication statusPublished - 1 Jan 2004

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