Abstract
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.
| Original language | English |
|---|---|
| Pages (from-to) | 1453-60 |
| Number of pages | 8 |
| Journal | Journal of Neural Transmission |
| Volume | 118 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Bicuculline
- Biophysics
- Convulsants
- Deep Brain Stimulation
- Disease Models, Animal
- GABA-A Receptor Agonists
- History, 20th Century
- Humans
- Macaca
- Male
- Muscimol
- Parkinson Disease
- Pedunculopontine Tegmental Nucleus
- Historical Article
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
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