Pedunculopontine stimulation from primate to patient

Erlick A C Pereira, Dipankar Nandi, Ned Jenkinson, John F Stein, Alexander L Green, Tipu Z Aziz

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

Original languageEnglish
Pages (from-to)1453-60
Number of pages8
JournalJournal of Neural Transmission
Issue number10
Publication statusPublished - Oct 2011


  • Animals
  • Bicuculline
  • Biophysics
  • Convulsants
  • Deep Brain Stimulation
  • Disease Models, Animal
  • GABA-A Receptor Agonists
  • History, 20th Century
  • Humans
  • Macaca
  • Male
  • Muscimol
  • Parkinson Disease
  • Pedunculopontine Tegmental Nucleus
  • Historical Article
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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