Pedunculopontine stimulation from primate to patient

Erlick A C Pereira; Dipankar Nandi; Ned Jenkinson; John F Stein; Alexander L Green; Tipu Z Aziz

doi:10.1007/s00702-011-0631-8

Pedunculopontine stimulation from primate to patient

Erlick A C Pereira, Dipankar Nandi, Ned Jenkinson, John F Stein, Alexander L Green, Tipu Z Aziz

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

Original language	English
Pages (from-to)	1453-60
Number of pages	8
Journal	Journal of Neural Transmission
Volume	118
Issue number	10
DOIs	https://doi.org/10.1007/s00702-011-0631-8
Publication status	Published - Oct 2011

Keywords

Animals
Bicuculline
Biophysics
Convulsants
Deep Brain Stimulation
Disease Models, Animal
GABA-A Receptor Agonists
History, 20th Century
Humans
Macaca
Male
Muscimol
Parkinson Disease
Pedunculopontine Tegmental Nucleus
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00702-011-0631-8

Cite this

@article{bfa4dccdbeec46ceb811ee0de6ad4223,

title = "Pedunculopontine stimulation from primate to patient",

abstract = "Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.",

keywords = "Animals, Bicuculline, Biophysics, Convulsants, Deep Brain Stimulation, Disease Models, Animal, GABA-A Receptor Agonists, History, 20th Century, Humans, Macaca, Male, Muscimol, Parkinson Disease, Pedunculopontine Tegmental Nucleus, Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "Pereira, {Erlick A C} and Dipankar Nandi and Ned Jenkinson and Stein, {John F} and Green, {Alexander L} and Aziz, {Tipu Z}",

year = "2011",

month = oct,

doi = "10.1007/s00702-011-0631-8",

language = "English",

volume = "118",

pages = "1453--60",

journal = "Journal of Neural Transmission",

issn = "0300-9564",

publisher = "Springer",

number = "10",

}

TY - JOUR

T1 - Pedunculopontine stimulation from primate to patient

AU - Pereira, Erlick A C

AU - Nandi, Dipankar

AU - Jenkinson, Ned

AU - Stein, John F

AU - Green, Alexander L

AU - Aziz, Tipu Z

PY - 2011/10

Y1 - 2011/10

N2 - Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

AB - Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

KW - Animals

KW - Bicuculline

KW - Biophysics

KW - Convulsants

KW - Deep Brain Stimulation

KW - Disease Models, Animal

KW - GABA-A Receptor Agonists

KW - History, 20th Century

KW - Humans

KW - Macaca

KW - Male

KW - Muscimol

KW - Parkinson Disease

KW - Pedunculopontine Tegmental Nucleus

KW - Historical Article

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00702-011-0631-8

DO - 10.1007/s00702-011-0631-8

M3 - Article

C2 - 21448675

SN - 0300-9564

VL - 118

SP - 1453

EP - 1460

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 10

ER -

Pedunculopontine stimulation from primate to patient

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this