PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL

Mustafa Farhat; Wayne Croft; Helen M Parry; Kriti Verma; Francesca A M Kinsella; Jinsong Xu; David Bone; Tina McSkeane; Shankara Paneesha; Guy Pratt; Paul Moss; Jianmin Zuo

doi:10.1038/s41375-024-02271-1

PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL

Mustafa Farhat, Wayne Croft, Helen M Parry, Kriti Verma, Francesca A M Kinsella, Jinsong Xu, David Bone, Tina McSkeane, Shankara Paneesha, Guy Pratt, Paul Moss, Jianmin Zuo

Immunology and Immunotherapy

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Abstract

B cell chronic lymphocytic leukemia (B-CLL) is a common leukemia subtype [1] and compromised immune function is a major clinical problem leading to increased mortality among patients [2].

Natural killer (NK) cells recognize and kill transformed or virally infected cells through mechanisms including granule-mediated cell lysis, cytokine release, and antibody-dependent cell-mediated cytotoxicity (ADCC) [3, 4]. However, NK cells are frequently dysfunctional in patients with cancer, and this profile is also seen in patients with CLL. An imbalance in the relative expression of activating and inhibitory receptors is an important mechanism of immune evasion, with decreased expression of the dominant activatory receptors NKG2D, DNAM-1 and NCRs as a common feature. This phenotype is associated with reduced degranulation and impaired lysis of target cells [5,6,7].

Original language	English
Pages (from-to)	1813-1817
Number of pages	5
Journal	Leukemia
Volume	38
Issue number	8
Early online date	9 May 2024
DOIs	https://doi.org/10.1038/s41375-024-02271-1
Publication status	E-pub ahead of print - 9 May 2024

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FarhatM2024PD-1Final published version, 1.4 MBLicence: Creative Commons: Attribution (CC BY)

Study of early immune reconstitution following stem cell transplantation: biological significance and therapeutic opportunities
Zuo, J. (Co-Investigator) & Moss, P. (Principal Investigator)
BLOODWISE
1/04/19 → 30/06/23
Project: Research

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title = "PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL",

abstract = "B cell chronic lymphocytic leukemia (B-CLL) is a common leukemia subtype [1] and compromised immune function is a major clinical problem leading to increased mortality among patients [2].Natural killer (NK) cells recognize and kill transformed or virally infected cells through mechanisms including granule-mediated cell lysis, cytokine release, and antibody-dependent cell-mediated cytotoxicity (ADCC) [3, 4]. However, NK cells are frequently dysfunctional in patients with cancer, and this profile is also seen in patients with CLL. An imbalance in the relative expression of activating and inhibitory receptors is an important mechanism of immune evasion, with decreased expression of the dominant activatory receptors NKG2D, DNAM-1 and NCRs as a common feature. This phenotype is associated with reduced degranulation and impaired lysis of target cells [5,6,7].",

author = "Mustafa Farhat and Wayne Croft and Parry, {Helen M} and Kriti Verma and Kinsella, {Francesca A M} and Jinsong Xu and David Bone and Tina McSkeane and Shankara Paneesha and Guy Pratt and Paul Moss and Jianmin Zuo",

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doi = "10.1038/s41375-024-02271-1",

language = "English",

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journal = "Leukemia",

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TY - JOUR

T1 - PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL

AU - Farhat, Mustafa

AU - Croft, Wayne

AU - Parry, Helen M

AU - Verma, Kriti

AU - Kinsella, Francesca A M

AU - Xu, Jinsong

AU - Bone, David

AU - McSkeane, Tina

AU - Paneesha, Shankara

AU - Pratt, Guy

AU - Moss, Paul

AU - Zuo, Jianmin

PY - 2024/5/9

Y1 - 2024/5/9

N2 - B cell chronic lymphocytic leukemia (B-CLL) is a common leukemia subtype [1] and compromised immune function is a major clinical problem leading to increased mortality among patients [2].Natural killer (NK) cells recognize and kill transformed or virally infected cells through mechanisms including granule-mediated cell lysis, cytokine release, and antibody-dependent cell-mediated cytotoxicity (ADCC) [3, 4]. However, NK cells are frequently dysfunctional in patients with cancer, and this profile is also seen in patients with CLL. An imbalance in the relative expression of activating and inhibitory receptors is an important mechanism of immune evasion, with decreased expression of the dominant activatory receptors NKG2D, DNAM-1 and NCRs as a common feature. This phenotype is associated with reduced degranulation and impaired lysis of target cells [5,6,7].

AB - B cell chronic lymphocytic leukemia (B-CLL) is a common leukemia subtype [1] and compromised immune function is a major clinical problem leading to increased mortality among patients [2].Natural killer (NK) cells recognize and kill transformed or virally infected cells through mechanisms including granule-mediated cell lysis, cytokine release, and antibody-dependent cell-mediated cytotoxicity (ADCC) [3, 4]. However, NK cells are frequently dysfunctional in patients with cancer, and this profile is also seen in patients with CLL. An imbalance in the relative expression of activating and inhibitory receptors is an important mechanism of immune evasion, with decreased expression of the dominant activatory receptors NKG2D, DNAM-1 and NCRs as a common feature. This phenotype is associated with reduced degranulation and impaired lysis of target cells [5,6,7].

U2 - 10.1038/s41375-024-02271-1

DO - 10.1038/s41375-024-02271-1

M3 - Letter

C2 - 38724674

SN - 0887-6924

VL - 38

SP - 1813

EP - 1817

JO - Leukemia

JF - Leukemia

IS - 8

ER -

PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL

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Study of early immune reconstitution following stem cell transplantation: biological significance and therapeutic opportunities

Cite this