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Abstract
Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.
| Original language | English |
|---|---|
| Pages (from-to) | 683-687 |
| Number of pages | 5 |
| Journal | Nature Reviews. Molecular Cell Biology |
| Volume | 11 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 15 Sept 2010 |
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Dive into the research topics of 'Pathways of mammalian replication fork restart'. Together they form a unique fingerprint.Research output
- 265 Citations
- 2 Article
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Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann, E., Orta, ML., Issaeva, N., Schultz, N. & Helleday, T., 1 Feb 2010, In: Molecular Cell. 37, 4, p. 492-502 11 p.Research output: Contribution to journal › Article › peer-review
493 Citations (Scopus)4 Downloads (Pure) -
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant, HE., Petermann, E., Schultz, N., Jemth, AS., Loseva, O., Issaeva, N., Johansson, F., Fernandez, S., McGlynn, P. & Helleday, T., 2 Sept 2009, In: The EMBO journal. 28, 17, p. 2601-2615 15 p.Research output: Contribution to journal › Article › peer-review
392 Citations (Scopus)8 Downloads (Pure)