Pathways of mammalian replication fork restart

Eva Petermann, Thomas Helleday

Research output: Contribution to journalReview articlepeer-review

265 Citations (Scopus)

Abstract

Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.
Original languageEnglish
Pages (from-to)683-687
Number of pages5
JournalNature Reviews. Molecular Cell Biology
Volume11
Issue number10
DOIs
Publication statusPublished - 15 Sep 2010

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