Passive smoking and aortic arch calcification in older Chinese never smokers: the Guangzhou Biobank Cohort Study

Lin Xu, Chao Qiang Jiang, Tai Hing Lam, G Neil Thomas, Wei Sen Zhang, Kar Keung Cheng

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    6 Citations (Scopus)


    OBJECTIVE: To study whether passive smoking is a risk factor for aortic arch calcification (AAC) among never smokers.

    BACKGROUND: We have previously reported that active smoking increases the risk of AAC, but the effect of passive smoking has not been reported.

    METHODS: We used baseline data of the Phase 1 Guangzhou Biobank Cohort Study (GBCS). 7702 older Chinese never smokers from the Phase 1 GBCS were included. Information on passive smoking and potential confounders were collected by standardized interviews and laboratory assays. AAC was diagnosed from chest X-ray by two experienced radiologists. Unconditional logistic regression was used to estimate odds ratios of AAC for passive smoking with adjustment for potential confounders.

    RESULTS: In women, the risk for aortic arch calcification (AAC) increased significantly with increasing duration of adulthood passive smoking exposure at home, at work and total duration of adulthood home and work exposure [adjusted odds ratio 1.24 (95% confidence interval 1.09-1.41) for high level of total exposure] (P for trend from 0.012 to 0.001). For passive smoking at home, at work and total exposure, significant trends of increasing severity of AAC with increasing duration of exposure were observed in men and women combined (P for trend from 0.05 to 0.002).

    CONCLUSION: Passive smoking is a risk factor for aortic arch calcification. Studies of passive smoking and AAC, especially in developing countries can generate important local evidence to raise awareness and to support public health measures to protect non-smokers from second-hand smoke.

    Original languageEnglish
    Pages (from-to)189-93
    Number of pages5
    JournalInternational Journal of Cardiology
    Issue number2
    Early online date27 Nov 2009
    Publication statusPublished - 14 Apr 2011


    • Age Distribution
    • Aged
    • Aged, 80 and over
    • Aorta, Thoracic
    • Aortic Arch Syndromes
    • Asian Continental Ancestry Group
    • Calcinosis
    • China
    • Cohort Studies
    • Female
    • Humans
    • Male
    • Middle Aged
    • Risk Factors
    • Sex Distribution
    • Tobacco Smoke Pollution


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