Parameters for reliable results in genetic association studies

I Dahlman; IA Eaves; R Kosoy; VA Morrison; Joanne King; Stephen Gough; Amit Allahabadia; Jayne Franklyn; J Tuomilheto; E Tuomelito-Wolf; F Cucca; C Guja; C Ionescu-Tirgoviste; H Stevens; P Carr; S Nutland; P McKinney; JP Shield; W Wang; HJ Cordell; N Walker; JA Todd; P Concannon

doi:10.1038/ng825

Parameters for reliable results in genetic association studies

I Dahlman
, IA Eaves
, R Kosoy
, VA Morrison
, Joanne King
, Stephen Gough
, Amit Allahabadia
, Jayne Franklyn
, J Tuomilheto
, E Tuomelito-Wolf
, F Cucca
, C Guja
, C Ionescu-Tirgoviste
, H Stevens
, P Carr
, S Nutland
, P McKinney
, JP Shield
, W Wang
, HJ Cordell

N Walker, JA Todd, P Concannon

Birmingham Medical School

Research output: Contribution to journal › Article

198 Citations (Scopus)

Abstract

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

Original language	English
Pages (from-to)	149-150
Number of pages	2
Journal	Nature Genetics
Volume	30
Issue number	2
DOIs	https://doi.org/10.1038/ng825
Publication status	Published - 1 Feb 2002

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SDG 3 Good Health and Well-being

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10.1038/ng825

Cite this

Dahlman, I., Eaves, IA., Kosoy, R., Morrison, VA., King, J., Gough, S., Allahabadia, A., Franklyn, J., Tuomilheto, J., Tuomelito-Wolf, E., Cucca, F., Guja, C., Ionescu-Tirgoviste, C., Stevens, H., Carr, P., Nutland, S., McKinney, P., Shield, JP., Wang, W., ... Concannon, P. (2002). Parameters for reliable results in genetic association studies. Nature Genetics, 30(2), 149-150. https://doi.org/10.1038/ng825

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abstract = "It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.",

author = "I Dahlman and IA Eaves and R Kosoy and VA Morrison and Joanne King and Stephen Gough and Amit Allahabadia and Jayne Franklyn and J Tuomilheto and E Tuomelito-Wolf and F Cucca and C Guja and C Ionescu-Tirgoviste and H Stevens and P Carr and S Nutland and P McKinney and JP Shield and W Wang and HJ Cordell and N Walker and JA Todd and P Concannon",

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Dahlman, I, Eaves, IA, Kosoy, R, Morrison, VA, King, J, Gough, S, Allahabadia, A, Franklyn, J, Tuomilheto, J, Tuomelito-Wolf, E, Cucca, F, Guja, C, Ionescu-Tirgoviste, C, Stevens, H, Carr, P, Nutland, S, McKinney, P, Shield, JP, Wang, W, Cordell, HJ, Walker, N, Todd, JA & Concannon, P 2002, 'Parameters for reliable results in genetic association studies', Nature Genetics, vol. 30, no. 2, pp. 149-150. https://doi.org/10.1038/ng825

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AU - Dahlman, I

AU - Eaves, IA

AU - Kosoy, R

AU - Morrison, VA

AU - King, Joanne

AU - Gough, Stephen

AU - Allahabadia, Amit

AU - Franklyn, Jayne

AU - Tuomilheto, J

AU - Tuomelito-Wolf, E

AU - Cucca, F

AU - Guja, C

AU - Ionescu-Tirgoviste, C

AU - Stevens, H

AU - Carr, P

AU - Nutland, S

AU - McKinney, P

AU - Shield, JP

AU - Wang, W

AU - Cordell, HJ

AU - Walker, N

AU - Todd, JA

AU - Concannon, P

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N2 - It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

AB - It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

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VL - 30

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EP - 150

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Parameters for reliable results in genetic association studies

Abstract

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