Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis

James E Scriven; Francois Cj Botha; Charlotte Schutz; David G Lalloo; Helen Wainwright; Graeme Meintjes

doi:10.1016/j.mmcr.2017.02.004

Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis

James E Scriven
, Francois Cj Botha
, Charlotte Schutz
, David G Lalloo
, Helen Wainwright
, Graeme Meintjes

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

Abstract

We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Medical mycology case reports
Volume	19
DOIs	https://doi.org/10.1016/j.mmcr.2017.02.004
Publication status	Published - Mar 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.mmcr.2017.02.004

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title = "Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis",

abstract = "We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.",

author = "Scriven, \{James E\} and Botha, \{Francois Cj\} and Charlotte Schutz and Lalloo, \{David G\} and Helen Wainwright and Graeme Meintjes",

year = "2018",

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doi = "10.1016/j.mmcr.2017.02.004",

language = "English",

volume = "19",

pages = "38--40",

journal = "Medical mycology case reports",

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T1 - Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis

AU - Scriven, James E

AU - Botha, Francois Cj

AU - Schutz, Charlotte

AU - Lalloo, David G

AU - Wainwright, Helen

AU - Meintjes, Graeme

PY - 2018/3

Y1 - 2018/3

N2 - We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

AB - We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

U2 - 10.1016/j.mmcr.2017.02.004

DO - 10.1016/j.mmcr.2017.02.004

M3 - Article

C2 - 29379704

SN - 2211-7539

VL - 19

SP - 38

EP - 40

JO - Medical mycology case reports

JF - Medical mycology case reports

ER -

Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis

Abstract

UN SDGs

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