Paracetamol poisoning unmasking factor VII deficiency

AP Chilton; T Hussain; Elwyn Elias

doi:10.1097/00042737-200204000-00019

Paracetamol poisoning unmasking factor VII deficiency

AP Chilton
, T Hussain
, Elwyn Elias

Birmingham Medical School

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose. (C) 2002 Lippincott Williams Wilkins.

Original language	English
Pages (from-to)	441-443
Number of pages	3
Journal	European Journal of Gastroenterology & Hepatology
Volume	14
Issue number	(4)
DOIs	https://doi.org/10.1097/00042737-200204000-00019
Publication status	Published - 1 Apr 2002

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title = "Paracetamol poisoning unmasking factor VII deficiency",

abstract = "We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose. (C) 2002 Lippincott Williams Wilkins.",

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N2 - We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose. (C) 2002 Lippincott Williams Wilkins.

AB - We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose. (C) 2002 Lippincott Williams Wilkins.

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JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

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Paracetamol poisoning unmasking factor VII deficiency

Abstract

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