Abstract
New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.
Original language | English |
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Pages (from-to) | 16509-16517 |
Number of pages | 9 |
Journal | Dalton Transactions |
Volume | 48 |
Issue number | 44 |
Early online date | 30 Oct 2019 |
DOIs | |
Publication status | Published - 2019 |