Pain-related evoked potentials are modulated across the cardiac cycle.

Louisa Edwards, K Inui, Christopher Ring, X Wang, R Kakigi

Research output: Contribution to journalArticle

43 Citations (Scopus)


Evidence suggests that the arterial baroreceptors modulate pain. To examine whether cortical processing of nociception is modulated by natural variations in arterial baroreceptor stimulation during the cardiac cycle, peak-to-peak amplitudes of the N2-P2 pain-related potential and pain ratings were recorded in response to noxious laser stimulation at different times during the cardiac cycle in 10 healthy males. Significant variations in the N2-P2 amplitudes occurred across the cardiac cycle, with smaller amplitudes midcycle, indicating that cortical processing of nociception was attenuated during systole compared to diastole. Pain ratings did not vary across the cardiac cycle. These data support the hypothesis that arterial baroreceptors modulate the processing of nociception during each cardiac cycle.
Original languageEnglish
Pages (from-to)488-94
Number of pages7
Issue number3
Publication statusPublished - 31 Jul 2008


  • arterial baroreceptors
  • pain-related evoked potentials
  • pain ratings
  • cardiac cycle


Dive into the research topics of 'Pain-related evoked potentials are modulated across the cardiac cycle.'. Together they form a unique fingerprint.

Cite this