Abstract
Objective: The aim of the COVER Study is to identify global outcomes and decision making for vascular procedures during the pandemic.
Background Data: During its initial peak, there were many reports of delays to vital surgery and the release of several guidelines advising later thresholds for vascular surgical intervention for key conditions.
Methods: An international multi-center observational study of outcomes after open and endovascular interventions.
Results: In an analysis of 1103 vascular intervention (57 centers in 19 countries), 71.6% were elective or scheduled procedures. Mean age was 67 ± 14 years (75.6% male). Suspected or confirmed COVID-19 infection was documented in 4.0%. Overall, in-hospital mortality was 11.0% [aortic interventions mortality 15.2% (23/151), amputations 12.1% (28/232), carotid interventions 10.7% (11/103), lower limb revascularisations 9.8% (51/521)]. Chronic obstructive pulmonary disease [odds ratio (OR) 2.02, 95% confidence interval (CI) 1.30–3.15] and active lower respiratory tract infection due to any cause (OR 24.94, 95% CI 12.57–241.70) ware associated with mortality, whereas elective or scheduled cases were lower risk (OR 0.4, 95% CI 0.22–0.73 and 0.60, 95% CI 0.45–0.98, respectively. After adjustment, antiplatelet (OR 0.503, 95% CI: 0.273–0.928) and oral anticoagulation (OR 0.411, 95% CI: 0.205–0.824) were linked to reduced risk of in-hospital mortality.
Conclusions: Mortality after vascular interventions during this period was unexpectedly high. Suspected or confirmed COVID-19 cases were uncommon. Therefore an alternative cause, for example, recommendations for delayed surgery, should be considered. The vascular community must anticipate longer term implications for survival.
Background Data: During its initial peak, there were many reports of delays to vital surgery and the release of several guidelines advising later thresholds for vascular surgical intervention for key conditions.
Methods: An international multi-center observational study of outcomes after open and endovascular interventions.
Results: In an analysis of 1103 vascular intervention (57 centers in 19 countries), 71.6% were elective or scheduled procedures. Mean age was 67 ± 14 years (75.6% male). Suspected or confirmed COVID-19 infection was documented in 4.0%. Overall, in-hospital mortality was 11.0% [aortic interventions mortality 15.2% (23/151), amputations 12.1% (28/232), carotid interventions 10.7% (11/103), lower limb revascularisations 9.8% (51/521)]. Chronic obstructive pulmonary disease [odds ratio (OR) 2.02, 95% confidence interval (CI) 1.30–3.15] and active lower respiratory tract infection due to any cause (OR 24.94, 95% CI 12.57–241.70) ware associated with mortality, whereas elective or scheduled cases were lower risk (OR 0.4, 95% CI 0.22–0.73 and 0.60, 95% CI 0.45–0.98, respectively. After adjustment, antiplatelet (OR 0.503, 95% CI: 0.273–0.928) and oral anticoagulation (OR 0.411, 95% CI: 0.205–0.824) were linked to reduced risk of in-hospital mortality.
Conclusions: Mortality after vascular interventions during this period was unexpectedly high. Suspected or confirmed COVID-19 cases were uncommon. Therefore an alternative cause, for example, recommendations for delayed surgery, should be considered. The vascular community must anticipate longer term implications for survival.
| Original language | English |
|---|---|
| Pages (from-to) | 630-635 |
| Number of pages | 6 |
| Journal | Annals of surgery |
| Volume | 273 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 30 Apr 2021 |
Keywords
- abdominal aortic aneurysm
- carotid endarterectomy
- COVID-19
- peripheral arterial disease
- vascular surgery