Outcome of liver transplantation in patients with hereditary bleeding disorders: a single centre UK experience

V Murthy, D Murray, S Hebballi, S Bramhall, W Lester, D Mutimer, J Wilde

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


INTRODUCTION: Patients with hereditary bleeding disorders who have developed end-stage liver disease as a consequence of hepatitis C infection (HCV) acquired from factor concentrates prior to the introduction of viral inactivation continue to be referred for liver transplantation.

METHODS: A retrospective review of case notes and electronic records was performed on all patients with bleeding disorders who have undergone liver transplantation at the University Hospital Birmingham (UHB).

RESULTS: Between 1990 and 2014, 35 liver transplants have been performed in 33 patients with hereditary bleeding disorders. The indication for transplantation was mainly end-stage liver disease secondary to HCV. Five patients had human immunodeficiency virus (HIV) co-infection. No excess mortality due to bleeding occurred in the peri or postoperative period. Median overall survival post transplant is 9.7 years. Overall survival rates at 1, 3 and 5 years are 90%, 72% and 64% respectively. The predominant cause of mortality was liver failure secondary to either recurrent HCV or recurrent hepatocellular carcinoma (HCC). The median overall survival in patients with HIV co-infection is shorter than in those with mono-infection but this is not statistically significant. Patients with a pre-existing HCC had a statistically significant shorter survival (2.4 years vs. 13.6 years, P = 0.007).

CONCLUSION: Liver transplantation has become an accepted treatment option for patients with hereditary bleeding disorders and HCV associated end-stage liver disease with survival rates similar to non-bleeding disorder patients.

Original languageEnglish
Publication statusPublished - 1 Mar 2016


  • haemophilia
  • HCV cirrhosis
  • liver transplantation


Dive into the research topics of 'Outcome of liver transplantation in patients with hereditary bleeding disorders: a single centre UK experience'. Together they form a unique fingerprint.

Cite this