Orthogonal functionalisation of α-helix mimetics

Anna Barnard; Kérya Long; David J. Yeo; Jennifer A. Miles; Valeria Azzarito; George M. Burslem; Panchami Prabhakaran; Thomas A. Edwards; Andrew J. Wilson

doi:10.1039/c4ob00915k

Orthogonal functionalisation of α-helix mimetics

Anna Barnard, Kérya Long, David J. Yeo, Jennifer A. Miles, Valeria Azzarito, George M. Burslem, Panchami Prabhakaran, Thomas A. Edwards, Andrew J. Wilson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is

Original language	English
Pages (from-to)	6794-6799
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	35
DOIs	https://doi.org/10.1039/c4ob00915k
Publication status	Published - 21 Sept 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is",

author = "Anna Barnard and K{\'e}rya Long and Yeo, {David J.} and Miles, {Jennifer A.} and Valeria Azzarito and Burslem, {George M.} and Panchami Prabhakaran and {A. Edwards}, Thomas and Wilson, {Andrew J.}",

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AU - Barnard, Anna

AU - Long, Kérya

AU - Yeo, David J.

AU - Miles, Jennifer A.

AU - Azzarito, Valeria

AU - Burslem, George M.

AU - Prabhakaran, Panchami

AU - A. Edwards, Thomas

AU - Wilson, Andrew J.

PY - 2014/9/21

Y1 - 2014/9/21

N2 - α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is

AB - α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is

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DO - 10.1039/c4ob00915k

M3 - Article

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EP - 6799

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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ER -

Orthogonal functionalisation of α-helix mimetics

Abstract

ASJC Scopus subject areas

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