Oropharyngeal Cancers in the East and the West – Implications of Aetiopathogenesis on Prognosis and Research

S. Chatterjee, S. Ghosh Laskar, H. Mehanna, C. M. Nutting, I. Mallick

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

There has been a surge in human papillomavirus (HPV)-positive oropharyngeal cancers (OPCs) in the West. Although the prognosis of HPV-positive OPC is good, de-escalation strategies have so far not been able to confirm comparable cancer control. We examine the strategies implemented across the globe to safely reduce toxicities in HPV-positive disease. HPV-negative OPC has a poorer prognosis and is more prevalent in Eastern countries. We outline the intensification strategies currently used in HPV-negative cancers, with an aim to better prognosis. With recent improvements in clinical trial frameworks in Eastern countries such as India, we discuss areas where joint collaborative research between Western and Eastern countries could further improve outcomes in OPC.

Original languageEnglish
Pages (from-to)510-519
Number of pages10
JournalClinical Oncology
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • East
  • HPV
  • oropharyngeal cancer
  • West

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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