Origin and early evolution of vertebrate skeletonization

Philip Donoghue, Ivan Sansom

Research output: Contribution to journalArticle

164 Citations (Scopus)


Data from living and extinct faunas of primitive vertebrates imply very different scenarios for the origin and evolution of the dermal and oral skeletal developmental system. A direct reading of the evolutionary relationships of living primitive vertebrates implies that the dermal scales, teeth, and jaws arose synchronously with a cohort of other characters that could be considered unique to jawed vertebrates: the dermoskeleton is primitively composed of numerous scales, each derived from an individual dental papilla; teeth are primitively patterned such that they are replaced in a classical conveyor-belt system. The paleontological record provides a unique but complementary perspective in that: 1) the organisms in which the skeletal system evolved are extinct and we have no recourse but to fossils if we aim to address this problem; 2) extinct organisms can be classified among, and in the same way as, living relatives; 3) a holistic approach to the incorporation of all data provides a more complete perspective on early vertebrate evolution. This combined approach is of no greater significance than in dealing with the origin of the skeleton and, combined with recent discoveries and new phylogenetic analyses, we have been able to test and reject existing hypotheses for the origin of the skeleton and erect a new model in their place.
Original languageEnglish
Pages (from-to)352-372
Number of pages21
JournalMicroscopy Research and Technique
Publication statusPublished - 1 Jan 2002


  • craniate
  • chordate
  • vertebrate
  • origin
  • splanchnocranium
  • skeleton
  • axial skeleton
  • neurocranium
  • dermoskeleton
  • evolution
  • histology


Dive into the research topics of 'Origin and early evolution of vertebrate skeletonization'. Together they form a unique fingerprint.

Cite this