Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Huy V Nguyen; Antoine Sallustrau; Jan Balzarini; Matthew R Bedford; John C Eden; Niki Georgousi; Nikolas J Hodges; Jonathan Kedge; Youcef Mehellou; Chris Tselepis; James H R Tucker

doi:10.1021/jm500246h

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Huy V Nguyen
, Antoine Sallustrau
, Jan Balzarini
, Matthew R Bedford
, John C Eden
, Niki Georgousi
, Nikolas J Hodges
, Jonathan Kedge
, Youcef Mehellou
, Chris Tselepis
, James H R Tucker

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

502 Downloads (Pure)

Abstract

Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

Original language	English
Pages (from-to)	5817-22
Number of pages	6
Journal	Journal of Medicinal Chemistry
Volume	57
Issue number	13
Early online date	6 Jun 2014
DOIs	https://doi.org/10.1021/jm500246h
Publication status	Published - 10 Jul 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Antineoplastic Agents
Cell Line, Tumor
Ferrous Compounds
Humans
Leukemia L1210
Nucleosides
Organometallic Compounds

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10.1021/jm500246h

Nguyen_et_al_Organometallic_Nucleoside_Analogues_Journal_Medicinal_Chemistry_Post-Print
Final version of record published as: Nguyen, Huy V., et al. "Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies." Journal of medicinal chemistry 57.13 (2014): 5817-5822. Available online at: http://dx.doi.org/10.1021/jm500246h Checked Jan 2016
Accepted author manuscript, 730 KBLicence: None: All rights reserved

Cite this

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title = "Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies",

abstract = "Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.",

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year = "2014",

month = jul,

day = "10",

doi = "10.1021/jm500246h",

language = "English",

volume = "57",

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journal = "Journal of Medicinal Chemistry",

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TY - JOUR

T1 - Organometallic nucleoside analogues with ferrocenyl linker groups

T2 - synthesis and cancer cell line studies

AU - Nguyen, Huy V

AU - Sallustrau, Antoine

AU - Balzarini, Jan

AU - Bedford, Matthew R

AU - Eden, John C

AU - Georgousi, Niki

AU - Hodges, Nikolas J

AU - Kedge, Jonathan

AU - Mehellou, Youcef

AU - Tselepis, Chris

AU - Tucker, James H R

PY - 2014/7/10

Y1 - 2014/7/10

N2 - Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

AB - Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

KW - Animals

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Ferrous Compounds

KW - Humans

KW - Leukemia L1210

KW - Nucleosides

KW - Organometallic Compounds

U2 - 10.1021/jm500246h

DO - 10.1021/jm500246h

M3 - Article

C2 - 24905419

SN - 0022-2623

VL - 57

SP - 5817

EP - 5822

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 13

ER -

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Abstract

UN SDGs

Keywords

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