Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Huy V Nguyen, Antoine Sallustrau, Jan Balzarini, Matthew R Bedford, John C Eden, Niki Georgousi, Nikolas J Hodges, Jonathan Kedge, Youcef Mehellou, Chris Tselepis, James H R Tucker

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)
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Abstract

Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

Original languageEnglish
Pages (from-to)5817-22
Number of pages6
JournalJournal of Medicinal Chemistry
Volume57
Issue number13
Early online date6 Jun 2014
DOIs
Publication statusPublished - 10 Jul 2014

Keywords

  • Animals
  • Antineoplastic Agents
  • Cell Line, Tumor
  • Ferrous Compounds
  • Humans
  • Leukemia L1210
  • Nucleosides
  • Organometallic Compounds

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