Abstract
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
Original language | English |
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Pages (from-to) | 5817-22 |
Number of pages | 6 |
Journal | Journal of Medicinal Chemistry |
Volume | 57 |
Issue number | 13 |
Early online date | 6 Jun 2014 |
DOIs | |
Publication status | Published - 10 Jul 2014 |
Keywords
- Animals
- Antineoplastic Agents
- Cell Line, Tumor
- Ferrous Compounds
- Humans
- Leukemia L1210
- Nucleosides
- Organometallic Compounds