Oral modified release multiple-unit particulate systems: Compressed pellets, microparticles and nanoparticles

Nihad Al-Hashimi, Nazish Begg, Raid G. Alany, Hany Hassanin, Amr Elshaer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional polymer coat, which results in a rapid release of the drug substance and the subsequent loss of sustained-release properties. This review brings to the forefront key formulation variables that are likely to influence the compaction of coated multiparticulates into sustained-release tablets. It focusses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles with a designated section on each. Furthermore, it explores the various approaches that are used to evaluate the compaction behaviour of particulate systems.

Original languageEnglish
Article number176
Issue number4
Publication statusPublished - Dec 2018


  • Compaction
  • Multiparticulate
  • Nano/microparticles
  • Pellets
  • Polymers

ASJC Scopus subject areas

  • Pharmaceutical Science


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