TY - CHAP
T1 - Optic Nerve Crush Injury in Rodents to Study Retinal Ganglion Cell Neuroprotection and Regeneration
AU - Ahmed, Zubair
PY - 2023/8/10
Y1 - 2023/8/10
N2 - Optic nerve crush injury is a useful model for studying the response of central nervous system neurons (CNS) to injury. A particular focus of this model has been to elucidate therapeutic factors in promoting neuroprotection and axon regeneration after injury. Here we describe a step-by-step protocol in accessing the optic nerve and creating a crush injury. This can be used to create a reproducible model to study the response of retinal ganglion cells (RGC), the main projection neurons of the eye, to injury.
AB - Optic nerve crush injury is a useful model for studying the response of central nervous system neurons (CNS) to injury. A particular focus of this model has been to elucidate therapeutic factors in promoting neuroprotection and axon regeneration after injury. Here we describe a step-by-step protocol in accessing the optic nerve and creating a crush injury. This can be used to create a reproducible model to study the response of retinal ganglion cells (RGC), the main projection neurons of the eye, to injury.
UR - https://www.scopus.com/pages/publications/85167528842
U2 - 10.1007/978-1-0716-3409-7_10
DO - 10.1007/978-1-0716-3409-7_10
M3 - Chapter (peer-reviewed)
SN - 9781071634080
T3 - Methods in Molecular Biology
SP - 99
EP - 105
BT - Retinal Ganglion Cells
A2 - Mead, Ben
PB - Humana Press
CY - New York, NY
ER -