TY - JOUR
T1 - Opposite cannabis-cognition associations in psychotic patients depending on family history
AU - the PEPs Group
AU - González-Pinto, Ana
AU - González-Ortega, Itxaso
AU - Alberich, Susana
AU - De Azúa, Sonia Ruiz
AU - Bernardo, Miguel
AU - Bioque, Miquel
AU - Cabrera, Bibiana
AU - Corripio, Iluminada
AU - Arango, Celso
AU - Lobo, Antonio
AU - Sánchez-Torres, Ana M.
AU - Cuesta, Manuel J.
AU - Ugarte, Amaia
AU - Fernández, Miryam
AU - Mezquida, Gisela
AU - Meseguer, Ana
AU - Vieta, Eduard
AU - Torrent, Carla
AU - Contreras, Fernando
AU - Albacete, Auria
AU - Alonso-Solís, Anna
AU - Rabella, Mireia
AU - Moreno-Izco, Lucía
AU - Usall, Judith
AU - Butjosa, Anna
AU - Ibáñez, Ángela
AU - Bobes, Julio
AU - Al-Halabí, Susana
AU - Zapata-Usábel, Ma Teresa
AU - Laporta-Herrero, Isabel
AU - Balanzá-Martínez, Vicent
AU - Bergé, Daniel
AU - Mané, Anna
AU - Rodriguez-Jimenez, Roberto
AU - Morales-Muñoz, Isabel
AU - Gutierrez, Miguel
AU - Zabala, Arantzazu
AU - Sarró, Salvador
AU - Landin-Romero, Ramón
AU - De La Serna, Elena
AU - Baeza, Inmaculada
AU - Parellada, Mara
AU - Espliego, Ana
AU - Juan, Julio San
AU - Aguilar, Eduardo
N1 - Publisher Copyright:
© 2016 González-Pinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/8
Y1 - 2016/8
N2 - The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
AB - The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
UR - http://www.scopus.com/inward/record.url?scp=84983504486&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0160949
DO - 10.1371/journal.pone.0160949
M3 - Article
C2 - 27513670
AN - SCOPUS:84983504486
SN - 1932-6203
VL - 11
JO - PLOS One
JF - PLOS One
IS - 8
M1 - e0160949
ER -