TY - JOUR
T1 - One for all and all for one: thymic epithelial stem cells and regeneration
AU - Blackburn, CC
AU - Manley, NR
AU - Boyd, RL
AU - Anderson, Graham
AU - Ritter, MA
PY - 2002/8/1
Y1 - 2002/8/1
N2 - It has long been believed that the thymic epithelial microenvironment originates from both the endodermal and ectodermal germ cell layers. However, a growing body of evidence indicates that such a dual origin is not the case, and that the diverse thymic epithelial populations all develop from a common epithelial stem cell. This article explores these data, investigates the identity of such cells and the signals that might control their expansion and differentiation, and considers the possibility of stem cell transplantation for thymic regeneration.
AB - It has long been believed that the thymic epithelial microenvironment originates from both the endodermal and ectodermal germ cell layers. However, a growing body of evidence indicates that such a dual origin is not the case, and that the diverse thymic epithelial populations all develop from a common epithelial stem cell. This article explores these data, investigates the identity of such cells and the signals that might control their expansion and differentiation, and considers the possibility of stem cell transplantation for thymic regeneration.
UR - http://www.scopus.com/inward/record.url?scp=0036679750&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(02)02265-2
DO - 10.1016/S1471-4906(02)02265-2
M3 - Article
C2 - 12133801
SN - 1471-4906
VL - 23
SP - 391
EP - 395
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -