Once weekly thyroxine treatment as a strategy to treat non-compliance

S Rangan, A A Tahrani, A F Macleod, P K Moulik

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Hypothyroidism is a common disorder, which is mainly treated in primary rather than secondary care. Once daily thyroxine replacement restores euthyroidism in most patients; some patients, however, remain hypothyroid despite adequate thyroxine replacement. Non-compliance is the most common cause of lack of response to thyroxine treatment. We describe two cases of primary hypothyroidism in which daily thyroxine treatment did not restore biochemical euthyroidism but once weekly thyroxine treatment was successful. In addition we review the evidence and discuss the differential diagnosis of lack of response to thyroxine treatment. Once weekly thyroxine treatment can be a safe, well-tolerated, and effective therapy for patients with non-compliance.

Original languageEnglish
Pages (from-to)e3
JournalPostgraduate Medical Journal
Issue number984
Publication statusPublished - Oct 2007
Externally publishedYes


  • Administration, Oral
  • Drug Administration Schedule
  • Female
  • Humans
  • Hypothyroidism
  • Middle Aged
  • Thyroxine
  • Treatment Refusal
  • Case Reports
  • Journal Article


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