Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines

R J Moots; Z Al-Saffar; D Hutchinson; S P Golding; P A Bacon; P J McLaughlin; Stephen Young

Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines

R J Moots, Z Al-Saffar, D Hutchinson, S P Golding, P A Bacon, P J McLaughlin, Stephen Young

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

It was noted that treatment of a patient with acute mania by haloperidol was associated with marked improvement in activity of rheumatoid arthritis. The objective of this study was to examine the effects of haloperidol on inflammatory cytokine release in vitro, as a potential mechanism to explain the in vivo anti-inflammatory effects of haloperidol.

Original language	English
Pages (from-to)	585-7
Number of pages	3
Journal	Annals of the Rheumatic Diseases
Volume	58
Issue number	9
Publication status	Published - Sept 1999

Keywords

Haloperidol
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Culture Techniques
Tumor Cells, Cultured
Interleukin-1
Dose-Response Relationship, Drug
Humans
Adult
Arthritis, Rheumatoid
Antipsychotic Agents
Female

Cite this

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title = "Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines",

abstract = "It was noted that treatment of a patient with acute mania by haloperidol was associated with marked improvement in activity of rheumatoid arthritis. The objective of this study was to examine the effects of haloperidol on inflammatory cytokine release in vitro, as a potential mechanism to explain the in vivo anti-inflammatory effects of haloperidol.",

keywords = "Haloperidol, Anti-Inflammatory Agents, Tumor Necrosis Factor-alpha, Culture Techniques, Tumor Cells, Cultured, Interleukin-1, Dose-Response Relationship, Drug, Humans, Adult, Arthritis, Rheumatoid, Antipsychotic Agents, Female",

author = "Moots, {R J} and Z Al-Saffar and D Hutchinson and Golding, {S P} and Bacon, {P A} and McLaughlin, {P J} and Stephen Young",

year = "1999",

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language = "English",

volume = "58",

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T1 - Old drug, new tricks

T2 - haloperidol inhibits secretion of proinflammatory cytokines

AU - Moots, R J

AU - Al-Saffar, Z

AU - Hutchinson, D

AU - Golding, S P

AU - Bacon, P A

AU - McLaughlin, P J

AU - Young, Stephen

PY - 1999/9

Y1 - 1999/9

N2 - It was noted that treatment of a patient with acute mania by haloperidol was associated with marked improvement in activity of rheumatoid arthritis. The objective of this study was to examine the effects of haloperidol on inflammatory cytokine release in vitro, as a potential mechanism to explain the in vivo anti-inflammatory effects of haloperidol.

AB - It was noted that treatment of a patient with acute mania by haloperidol was associated with marked improvement in activity of rheumatoid arthritis. The objective of this study was to examine the effects of haloperidol on inflammatory cytokine release in vitro, as a potential mechanism to explain the in vivo anti-inflammatory effects of haloperidol.

KW - Haloperidol

KW - Anti-Inflammatory Agents

KW - Tumor Necrosis Factor-alpha

KW - Culture Techniques

KW - Tumor Cells, Cultured

KW - Interleukin-1

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Adult

KW - Arthritis, Rheumatoid

KW - Antipsychotic Agents

KW - Female

M3 - Article

C2 - 10460194

SN - 0003-4967

VL - 58

SP - 585

EP - 587

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 9

ER -

Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines

Abstract

Keywords

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