Abstract
We report a 24-year-old woman with active acromegaly despite pituitary surgery and irradiation who received continuous octreotide LAR treatment for the control of GH excess throughout her pregnancy. The patient delivered a healthy girl following an uneventful pregnancy. Despite a substantial materno-fetal transfer of octreotide, postnatal development was normal with length parameters around the 50th percentile at 3 months of age. In almost all previously described cases (n = 13) octreotide was stopped after the diagnosis of pregnancy was established. No side-effects of mother or fetus have been reported. Octreotide treatment in pregnancy seems to be feasible and safe. Due to the still-limited number of reported cases, the potential benefits of octreotide treatment should be weighed carefully against its possible risks.
| Original language | English |
|---|---|
| Pages (from-to) | 411-5 |
| Number of pages | 5 |
| Journal | Clinical Endocrinology |
| Volume | 55 |
| Issue number | 3 |
| Publication status | Published - Sept 2001 |
Keywords
- Acromegaly
- Adenoma
- Adult
- Antineoplastic Agents, Hormonal
- Delayed-Action Preparations
- Female
- Humans
- Maternal-Fetal Exchange
- Octreotide
- Pituitary Neoplasms
- Pregnancy
- Pregnancy Complications, Neoplastic
- Pregnancy Outcome
- Prenatal Care