OCT assisted quantification of vitreous inflammation in uveitis

Xiaoxuan Liu, Aditya Kale, Giovanni Ometto, Giovanni Montesano, Alice Sitch, Nicholas Capewell, Charlotte Radovanovic, Nicholas Bucknall, Nicholas Beare, David Moore, Pearse Keane, David P Crabb, Alastair Denniston

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Abstract

Purpose: Vitreous haze (VH) is a key marker of inflammation in uveitis but limited by its subjectivity. Optical coherence tomography (OCT) has potential as an objective, noninvasive method for quantifying VH. We test the hypotheses that OCT can reliably quantify VH and the measurement is associated with slit-lamp based grading of VH.

Methods: In this prospective study, participants underwent three repeated OCT macular scans to evaluate the within-eye reliability of the OCT vitreous intensity (VI). Association between OCT VI and clinical findings (including VH grade, phakic status, visual acuity [VA], anterior chamber cells, and macular thickness) were assessed.

Results: One hundred nineteen participants were included (41 healthy participants, 32 patients with uveitis without VH, and 46 patients with uveitis with VH). Within-eye test reliability of OCT VI was high in healthy eyes and in all grades of VH (intraclass correlation coefficient [ICC] > 0.79). Average OCT VI was significantly different between healthy eyes and uveitic eyes without and uveitic eyes with VH, and was associated with increasing clinical VH grade (P < 0.05). OCT VI was significantly associated with VA, whereas clinical VH grading was not. Cataract was also associated with higher OCT VI (P = 0.03).

Conclusions: OCT VI is a fast, noninvasive, objective, and automated method for measuring vitreous inflammation. It is associated with clinician grading of vitreous inflammation and VA, however, it can be affected by media opacities.

Translational Relevance: OCT imaging for quantifying vitreous inflammation shows high within-eye repeatability and is associated with clinical grading of vitreous haze. OCT measurements are also associated with visual acuity but may be affected by structures anterior to the acquisition window, such as lens opacity and other anterior segment changes.
Original languageEnglish
Article number3
JournalTranslational Vision Science & Technology
Volume11
Issue number1
DOIs
Publication statusPublished - 4 Jan 2022

Bibliographical note

Funding Information:
Commercial relationships: A.K.D. and P.A.K. receive a proportion of their funding from the Department of Health’s NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology. The views expressed in this article are those of the author(s) and not necessarily those of the NIHR, or the Department of Health and Social Care. G.O., X.L., D.C., and A.K.D. receive a proportion of their funding for this project from the Wellcome Trust, through a Health Improvement Challenge grant (200141/Z/15/Z).

Funding Information:
Supported by the Wellcome Trust (200141/Z/15/Z). Commercial relationships: A.K.D. and P.A.K. receive a proportion of their funding from the Department of Health?s NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology. The views expressed in this article are those of the author(s) and not necessarily those of the NIHR, or the Department of Health and Social Care. G.O., X.L., D.C., and A.K.D. receive a proportion of their funding for this project from the Wellcome Trust, through a Health Improvement Challenge grant (200141/Z/15/Z).

Publisher Copyright:
© 2022 The Authors.

Keywords

  • Imaging
  • Inflammation
  • Optical coherence tomography
  • Uveitis
  • Vitreous haze

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

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