Abstract
Audits of adjuvant chemotherapy for breast cancer have revealed that obese patients receive a lower relative dose intensity (RDI). However, interpretation of these studies is complicated by the variable use of cytokine growth factors, empiric dose capping and first cycle dose reductions. We have analysed the impact of obesity on RDI in a cohort of 662 patients that is not confounded by these factors. Patients were classified as overweight or obese on the basis of a body mass index (BMI)>or=25 kg/m2. The mean RDI in patients with BMI>or=25 kg/m2 was actually significantly greater than in those with BMI
Original language | English |
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Pages (from-to) | 544-8 |
Number of pages | 5 |
Journal | European Journal of Cancer |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Feb 2007 |
Keywords
- breast cancer
- myelosuppression
- obesity
- chemotherapy