TY - JOUR
T1 - Obesity, high-sensitive C-reactive protein and snoring in older Chinese: the Guangzhou Biobank Cohort Study
AU - Lao, XQ
AU - Thomas, Graham
AU - Jiang, Chao
AU - Zhang, Wei
AU - Adab, Peymane
AU - Lam, T
AU - Cheng, Kar
PY - 2010/11/1
Y1 - 2010/11/1
N2 - BACKGROUND: abitual snoring and elevated high-sensitive C-reactive protein (HsCRP) have both been associated with increased risk of cardiovascular disease. However, snoring and HsCRP are elevated in obese states which may thus be the primary determinant of both. We therefore investigated whether snoring may mediate the increased vascular risk directly through increased inflammation as indicated by HsCRP levels or if other determinants predominated in a large older Chinese population. METHODS: A total of 2508 males and 5709 females aged 50-85 years received a medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and HsCRP. Information on self-reported snoring status was collected by standardized interview. RESULTS: The age-adjusted geometric mean HsCRP concentrations increased significantly with higher snoring frequency in both genders (linear trend, p=0.02 for men and p
AB - BACKGROUND: abitual snoring and elevated high-sensitive C-reactive protein (HsCRP) have both been associated with increased risk of cardiovascular disease. However, snoring and HsCRP are elevated in obese states which may thus be the primary determinant of both. We therefore investigated whether snoring may mediate the increased vascular risk directly through increased inflammation as indicated by HsCRP levels or if other determinants predominated in a large older Chinese population. METHODS: A total of 2508 males and 5709 females aged 50-85 years received a medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and HsCRP. Information on self-reported snoring status was collected by standardized interview. RESULTS: The age-adjusted geometric mean HsCRP concentrations increased significantly with higher snoring frequency in both genders (linear trend, p=0.02 for men and p
KW - Obesity
KW - Snoring
KW - Chinese
KW - High-sensitive C-reactive protein
U2 - 10.1016/j.rmed.2010.06.003
DO - 10.1016/j.rmed.2010.06.003
M3 - Article
C2 - 20587368
VL - 104
SP - 1750
EP - 1756
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 11
ER -
