Abstract
There is an urgent need for improved respiratory surveillance of preterm infants. Gas in scattering media absorption spectroscopy (GASMAS) is emerging as a potential clinical cutaneous monitoring tool of lung functions in neonates. A challenge in the clinical translation of GASMAS is to obtain sufficiently high signal-to-noise ratios in the measurements, since the light attenuation is high in human tissue. Previous GASMAS studies on piglets have shown higher signal quality with an internal source, as more light propagates through the lung and the loss due to scattering and absorption is less. In this article we simulated light propagation with an intratracheal and a dermal source, and investigated the signal quality and lung volume probed. The results suggest that GASMAS has the potential to measure respiratory volumes; and the sensitivity is higher for an intratracheal source which also enables to probe most of the lung.
| Original language | English |
|---|---|
| Article number | e202200041 |
| Number of pages | 12 |
| Journal | Journal of Biophotonics |
| Volume | 15 |
| Issue number | 7 |
| Early online date | 27 Mar 2022 |
| DOIs | |
| Publication status | E-pub ahead of print - 27 Mar 2022 |
Bibliographical note
Funding Information:The authors like to thank Monisha Chakravarty for helping with segmentation. The research leading to these results was funded by Science Foundation Ireland project no. SFI/15/RP/2828. Open access funding provided by IReL.
Publisher Copyright:
© 2022 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.
Keywords
- computational model of a thorax
- light transport
- preterm infants
- tuneable diode laser absorption spectroscopy
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- General Biochemistry,Genetics and Molecular Biology
- General Engineering
- General Physics and Astronomy