Novel inositol containing phospholipids and phosphates: their synthesis and possible new roles in cellular signalling

Philip J. Hughes, Robert H. Michell

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Details of the widely employed Ptdlns(4,5)P2 hydrolysis receptor-stimulated signalling pathway continue to be elucidated rapidly. However, it has recently become apparent that numerous other inositol lipids and phosphates are widespread and are likely to have important cellular functions. In this review, we focus particularly on three rapidly progressing areas: the synthesis and possible functions of 3-phosphorylated inositol lipids, particularly phosphatidylinositol 3,4,5-trisphosphate; the roles of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in coordinating intracellular Cat+ mobilization and Ca2+ influx in stimulated cells; and the metabolism and possible functions of other inositol polyphosphates and of inositol polyphosphate pyrophosphates.

Original languageEnglish
Pages (from-to)383-400
Number of pages18
JournalCurrent Opinion in Neurobiology
Volume3
Issue number3
DOIs
Publication statusPublished - 1 Jan 1993

ASJC Scopus subject areas

  • Neuroscience(all)

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